Andrew G. Roberts

roberts

ORGANIC & BIOORGANIC CHEMISTRY

Assistant Professor of Chemistry

B.S.                 University of California, San Diego, 2008
Ph.D.              University of California, Los Angeles, 2013
Postdoc         Memorial Sloan Kettering, NIH Ruth Kirschstein Fellow, 2013 – 2017

 

Phone: 801-213-3682
Office: 2210 HEB
Email: roberts@chem.utah.edu

Research Group

Publication List

ACTIVITIES AND AWARDS

  • NIH Ruth L. Kirschstein National Research Service Award (F32, MSKCC), 2014 – 2017
  • Graduate Dissertation Year Fellowship (UCLA), 2012 – 2013
  • Senior Christopher S. Foote Fellowship in Organic Chemistry (UCLA), 2011 – 2013

RESEARCH INTERESTS

  • The Roberts laboratory will be open August 2017
  • Research in the Roberts laboratory is focused on the design and chemical synthesis of peptide-based therapeutics. Our chemistry draws inspiration from the unique structural elements and function present in ribosomally synthesized and post-translationally modified peptides (RiPPs) and miniproteins. We are interested in the development of chemoselective methods for peptide ligation, macrocyclization, glycosylation and modification.
  • Additionally, we are interested in discovering catalysis methods for the cleavage and functionalization of carbon-nitrogen (C–N) bonds in small molecule and natural product synthesis efforts.

SELECTED PUBLICATIONS

  • Adam M. Levinson, John H. McGee*, Andrew G. Roberts*, Gardner Creech, Ting Wang, Michael T. Peterson, Ronald C. Hendrickson, Gregory L. Verdine, Samuel J. Danishefsky* “Total Chemical Synthesis and Folding of All-L and All-D Variants of Oncogenic KRas(G12V)” J. Am. Chem. Soc.2017, 7632 – 7639. DOI: 10.1021/jacs.7b02988
  • Andrew G. Roberts*, Eric V. Johnston, Jae-Hung Shieh, Joseph P. Sondey, Ronald C. Hendrickson, Malcolm A. S. Moore, Samuel J. Danishefsky* “Fully Synthetic Granulocyte Colony-Stimulating Factor (G-CSF) Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain Unprotected Peptides” J. Am. Chem. Soc.2015, 137, 13167 – 13175. DOI:10.1021/jacs.5b08754
  • Hui Ding, Andrew G. Roberts, Patrick G. Harran* “Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement” Chem. Sci.2013, 4, 303 – 306. DOI:10.1039/C2SC21651E
  • Hui Ding, Andrew G. Roberts, Patrick G. Harran* “Synthetic (±)-Axinellamines Deficient in Halogen” Angew. Chem. Int. Ed.2012, 51, 4340 – 4343. DOI:10.1002/anie.201200205 (VIP paper)
  • Qingyi Li, Paul Hurley, Hui Ding, Andrew G. Roberts, Radha Akella, Patrick G. Harran* “Exploring Symmetry-Based Logic for a Synthesis of Palau’amine” J. Org. Chem.2009, 74, 5909 – 5919. DOI:10.1021/jo900755r
Last Updated: 8/16/17